Glossary entry (derived from question below)
Jul 26, 2010 07:49
13 yrs ago
5 viewers *
Spanish term
25 years' experience
Native in: English
Works in: Spanish to English, French to English, Italian to English, and 2 more.
0 horas
Spanish to English
Medical
Medical: Pharmaceuticals
clinical trials
predosis: (a.m. a las 0 horas) y a 1, 1,5, 2, 3, 4, 8, 12, 18 y 24 horas posdosis.
the above is a schedule of blood tests, what I want to know is what exactly is meant by 0 horas? Does it mean 12.00 am (i.e. midnight) or just "zero hour" in the sense of when the tests begin?
the above is a schedule of blood tests, what I want to know is what exactly is meant by 0 horas? Does it mean 12.00 am (i.e. midnight) or just "zero hour" in the sense of when the tests begin?
Proposed translations
(English)
| 4 +3 | 0 hours |
Emma Goldsmith
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| 5 +2 | hour 0 |
Muriel Vasconcellos
|
Change log
Sep 1, 2011 08:49: Emma Goldsmith Created KOG entry
Proposed translations
+3
2 mins
Emma Goldsmith
Spain
Spain
Native in English
Specializes in field
Spain
25 years of medical translations
Native in: English (Variant: UK) 
Works in: Spanish to English
Related KudoZ points
:
240
Selected
0 hours
It's talking about post-dose.
So 0 hours is the time that the first dose is taken. Nothing to do with midnight.
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Note added at 19 mins (2010-07-26 08:09:53 GMT)
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This refers to taking the first blood sample pre-dose in the morning (a.m.), i.e. a baseline sample.
If it really meant midnight it would put "00.00 horas".
0, 1, 12 horas is a typical way of specifying time intervals.
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Note added at 4 hrs (2010-07-26 11:55:47 GMT)
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Samples for HCV RNA determination were collected at Screening, Day 1 (0, 1, 2 and 6 hours post-dose)
http://www.natap.org/2010/EASL/EASL_62.htm
using all concentration-time data (i.e., from four blood samples collected at 0, 1, 2 and 3 hours post-dose)
http://linkinghub.elsevier.com/retrieve/pii/S105324980100272...
Time Frame: Comparison of values from blood collected at 0, 12 and 24 hours post-dose
http://apps.who.int/trialsearch/trial.aspx?trialid=NCT007749...
I agree with Muriel that you can also say "hour 0", but in the context of Clifford's phrase it may be more comfortable to use "0 hours"
So 0 hours is the time that the first dose is taken. Nothing to do with midnight.
--------------------------------------------------
Note added at 19 mins (2010-07-26 08:09:53 GMT)
--------------------------------------------------
This refers to taking the first blood sample pre-dose in the morning (a.m.), i.e. a baseline sample.
If it really meant midnight it would put "00.00 horas".
0, 1, 12 horas is a typical way of specifying time intervals.
--------------------------------------------------
Note added at 4 hrs (2010-07-26 11:55:47 GMT)
--------------------------------------------------
Samples for HCV RNA determination were collected at Screening, Day 1 (0, 1, 2 and 6 hours post-dose)
http://www.natap.org/2010/EASL/EASL_62.htm
using all concentration-time data (i.e., from four blood samples collected at 0, 1, 2 and 3 hours post-dose)
http://linkinghub.elsevier.com/retrieve/pii/S105324980100272...
Time Frame: Comparison of values from blood collected at 0, 12 and 24 hours post-dose
http://apps.who.int/trialsearch/trial.aspx?trialid=NCT007749...
I agree with Muriel that you can also say "hour 0", but in the context of Clifford's phrase it may be more comfortable to use "0 hours"
Peer comment(s):
| agree |
John Cutler
50 mins
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Thanks John
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| agree |
neilmac
: Shouldn't really "agree" because I didn't actually know, but it is very useful for future reference, cheers :)
1 hr
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Thanks Neil
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| agree |
franglish
4 hrs
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Thanks Franglish
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4 KudoZ points awarded for this answer.
Comment: "many thanks"
+2
3 hrs
Muriel Vasconcellos
United States
United States
Native in English
Works in field
United States
Each translation a gem!
Native in: English (Variant: US)
Works in: Spanish to English, Portuguese to English
Related KudoZ points
:
267
hour 0
This is how we say it in US English in text referring to dose administration. That is parallel in grammatical structure to 'day 10', 'week 2', etc.
23,200 hits for ["hour 0"+dose] - examples:
Maximum Plasma Concentration (Cmax) [Time Frame: serial pharmacokinetic blood samples drawn within one hour prior to dosing (hour 0) and at 0.5, 1, 2, 2.5, ...
apps.who.int/trialsearch/trial.aspx?trialid=NCT00727272
Jun 7, 2010 ... Time From the First Dose of Study Drug to a Confirmed > 4 mEq/L Increase ... on Day-1 and within 24 hours of Hour 0 in the Treatment Period. ...
clinicaltrials.gov/ct2/show/NCT00435591
The numbers of discrepancies of dosing insulin were respectively 8-5-6-14 at 0.1 U/hour, 0-6-3-6 at 0.2 U/hour and 2-3-0-0 at 0.3 U/hour. ...
ccforum.com/content/14/S1/P573
... the dorzolamide-timolol combination reduced IOP relative to the 0.5% timolol baseline by approximately 14% at hour 0 (just before the morning dose), ...
www.ncbi.nlm.nih.gov/pubmed/10598691
The E2 was given at a dose of 0.2 mg at Hour 0 and 0.1 mg at Hours 4 and 8. Blood samples were taken for E2 and LH assay every 4 h from Hours 0 to 24, ...
www.biolreprod.org/content/77/3/543.full
or twice daily dose. Drug concentrations reached steady state by day 15, in both groups. The mean pre-dose itraconazole serum concentration at hour 0, ...
jac.oxfordjournals.org/cgi/reprint/34/2/247.pdf
Significant dose trend is present from hour 2 through. houM2(P<.05). treatment group demonstrated a sig¬ nificant decrease in IOP from prestudy hour 0 to ...
archopht.ama-assn.org/cgi/reprint/109/1/46.pdf
Patients received cytarabine 1.0 g/m2 as a 2-hour infusion every 12 hours for 4 days (eight doses) starting at hour 0, day 0. Mitoxantrone 12 mg/m2 was ...
jco.ascopubs.org/cgi/content/full/21/15/2940
23,200 hits for ["hour 0"+dose] - examples:
Maximum Plasma Concentration (Cmax) [Time Frame: serial pharmacokinetic blood samples drawn within one hour prior to dosing (hour 0) and at 0.5, 1, 2, 2.5, ...
apps.who.int/trialsearch/trial.aspx?trialid=NCT00727272
Jun 7, 2010 ... Time From the First Dose of Study Drug to a Confirmed > 4 mEq/L Increase ... on Day-1 and within 24 hours of Hour 0 in the Treatment Period. ...
clinicaltrials.gov/ct2/show/NCT00435591
The numbers of discrepancies of dosing insulin were respectively 8-5-6-14 at 0.1 U/hour, 0-6-3-6 at 0.2 U/hour and 2-3-0-0 at 0.3 U/hour. ...
ccforum.com/content/14/S1/P573
... the dorzolamide-timolol combination reduced IOP relative to the 0.5% timolol baseline by approximately 14% at hour 0 (just before the morning dose), ...
www.ncbi.nlm.nih.gov/pubmed/10598691
The E2 was given at a dose of 0.2 mg at Hour 0 and 0.1 mg at Hours 4 and 8. Blood samples were taken for E2 and LH assay every 4 h from Hours 0 to 24, ...
www.biolreprod.org/content/77/3/543.full
or twice daily dose. Drug concentrations reached steady state by day 15, in both groups. The mean pre-dose itraconazole serum concentration at hour 0, ...
jac.oxfordjournals.org/cgi/reprint/34/2/247.pdf
Significant dose trend is present from hour 2 through. houM2(P<.05). treatment group demonstrated a sig¬ nificant decrease in IOP from prestudy hour 0 to ...
archopht.ama-assn.org/cgi/reprint/109/1/46.pdf
Patients received cytarabine 1.0 g/m2 as a 2-hour infusion every 12 hours for 4 days (eight doses) starting at hour 0, day 0. Mitoxantrone 12 mg/m2 was ...
jco.ascopubs.org/cgi/content/full/21/15/2940
Peer comment(s):
| agree |
Emma Goldsmith
: yes, this is right too :)
29 mins
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Hi Emma! I didn't read your answer carefully. I glanced at it quickly took it to mean the "midnight" interpretation. So yes, it's a different way of saying the same thing.
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| agree |
argosys
3 hrs
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Thank yoU!
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Discussion